Molecular Endocrinology of Hydroxysteroid Dehydrogenases*
نویسندگان
چکیده
منابع مشابه
Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.
11beta-hydroxysteroid dehydrogenases (HSDs) interconvert active 11-hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11-keto derivatives (cortisone, 11-dehydrocorticosterone). 11beta-HSD type 1 is a predominant reductase that regenerates active glucocorticoids in expressing cells, thus amplifying local glucocorticoid action, whereas 11beta-HSD type 2 catalyzes rapid dehydrogena...
متن کامل11β-Hydroxysteroid Dehydrogenases in the Regulation of Tissue Glucocorticoid Availability
The regulation of tissue-specific actions of glucocorticoids (GCs) goes far beyond the effects of the fluctuation of their circulating levels and can be controlled by local intracellular en‐ zymes. In the past few years, evidence is being gathered not only on the relevance of such enzymes to GC physiological actions but also on their involvement in the pathophysiology of certain chronic disease...
متن کاملStereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
The present studies are concerned with the determination of the steric course of the transfer of hydrogen catalyzed by hydroxysteroid dehydrogenases. The classic work of Vennesland et al. (l-3) has demonstrated that pyridine nucleotide-linked dehydrogenases catalyze a direct and stereospecific transfer of hydrogen between the substrate and the para position of the nicotinamide ring of the nucle...
متن کاملGenetic manipulation of 11 -hydroxysteroid dehydrogenases in mice
Paterson, Janice M., Jonathan R. Seckl, and John J. Mullins. Genetic manipulation of 11 -hydroxysteroid dehydrogenases in mice. Am J Physiol Regul Integr Comp Physiol 289: R642–R652, 2005; doi:10.1152/ajpregu.00017.2005.— 11 -Hydroxysteroid dehydrogenases (HSDs) interconvert active 11-hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11-keto derivatives (cortisone, 11-dehydroco...
متن کاملIdiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 1997
ISSN: 0163-769X,1945-7189
DOI: 10.1210/edrv.18.3.0302